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KMID : 0363619960170020296
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Journal of Korean Oriental Medicine
1996 Volume.17 No. 2 p.296 ~ p.302
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Pericarpium Citri Nobilis Viride INHIBITS HISTAMINE-INDUCED CONTRACTILE RESPONSES OF AIRWAY SMOOTH MUSCLE
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한종현/Han, Jong-Hyun
하경화/이지선/이광규/진천식/Ha, Kyung-Hwa/Lee, Ji-Sun/Lee, Kwang-Gyu/Jin, Chun-Sik
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Abstract
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Pericatpium Citri Nobilis Viride, a traditional herb medicine, has been used in Korea and China for many centuries as a treatment for respiratory disease. The purpose of the present study was to determine the effect of Pericarpium Citri Nobilis Viride on histamine-induced tracheal smooth muscle contraction in rats. Guinea pigs(500g, female) were killed by CO₂exposure and a segment (8-10mm) of the thoracic trachea from each gLnnea pig was cut into equal segments and mounted ´in pairs´ in a tissue bath. Contractile force was measured with force displacement transducers under 0.5g loading tension. The dose of histamine which evoked 50% of maximal response (ED_(50)) was obtained from cumulative dose response curves for histamine (10^(-7)-10^(4)M). Contractions evoked by histamine (ED_(50))
were inhihited significantly by Pericarpium Citri Nobilis Viride. The mean percent inhibition was 53.7% (p<0.05) after 1.5mg/ml Pericarpium Citri Nobilis Viride, and 87.7% (p<0.01) after 5.0mg/ml Pericarpium Citri Nobilis Viride. Propranolol (10^(-7)M) slightly but significantly attenuated the inhibitory effects of Pericarpium Citri Nobilis Viride. Following treatment with propranolol, the mean percent in zibition caused by 1.5 and 5.0mg/ml Pericarpium Citri Nobilis Viride. Indomethacin and methylene blue (10^(-7)M) did not significantly alter the inhibitory effect of Pericarpium Citri Nobilis Viride. These results indicate that Pericarpium Citri Nobilis Viride can relax histamine-induced contraction of guinea pig tracheal smooth muscle, and that this inhibition involves, in part, symphathe is nerve system.
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